| 2025-03-08 12:00:00March 8, 2025 | Leigh Leopards Reserves vs Leeds Reserves | 22 - 30 | Reserves | Golborne Parkside |
| 2025-03-15 13:00:00March 15, 2025 | Warrington Reserves vs Leigh Leopards Reserves | 58 - 08 | Reserves | Victoria Park |
| 2025-03-29 14:00:00March 29, 2025 | Leigh Leopards Reserves vs Wakefield Reserves | 28 - 60 | Reserves | Golborne Parkside |
| 2025-04-13 13:00:00April 13, 2025 | Castleford Reserves vs Leigh Leopards Reserves | 18 - 36 | Reserves | The Jungle |
| 2025-04-27 14:00:00April 27, 2025 | Salford Reserves vs Leigh Leopards Reserves | 22 - 38 | Reserves | Salford Stadium |
| 2025-05-10 12:00:00May 10, 2025 | Leigh Leopards Reserves vs Bradford Reserves | 78 - 06 | Reserves | Golborne Parkside |
| 2025-05-24 14:00:00May 24, 2025 | Leigh Leopards Reserves vs Hull FC Reserves | 30 - 38 | Reserves | Golborne Parkside |
| 2025-06-14 11:00:00June 14, 2025 | Huddersfield Reserves vs Leigh Leopards Reserves | 46 - 24 | Reserves | Laund Hill |
| 2025-07-05 13:00:00July 5, 2025 | Leigh Leopards Reserves vs Wigan Reserves | 18 - 30 | Reserves | Golborne Parkside |
| 2025-07-19 13:00:00July 19, 2025 | St Helens Reserves vs Leigh Leopards Reserves | 50 - 16 | Reserves | The BrewDog Stadium |
| 2025-08-16 13:00:00August 16, 2025 | Leigh Leopards Reserves vs Hull KR Reserves (Copy) | 30 - 22 | Reserves | Golborne Parkside |
| 2025-09-06 12:30:00September 6, 2025 | Warrington Wolves Reserves vs Leigh Leopards Reserves | 48 - 10 | Reserves | Halliwell Jones Stadium |
